By Lynn L. Bergeson and Carla N. Hutton
 
Colorado State University (CSU) announced on April 11, 2023, that its chemists, led by Eugene Chen, University Distinguished Professor in the Department of Chemistry, have created a synthetic polyhydroxyalkanoate (PHA) platform. CSU states that PHAs are a class of polymers naturally created by living microorganisms or synthetically produced from biorenewable feedstocks. While they are biodegradable in the ambient environment, they are brittle and cannot easily be melt-processed and recycled. According to CSU, the synthetic PHA platform addresses each of these problems, “paving the way for a future in which PHAs can take off in the marketplace as truly sustainable plastics.”
 
The researchers searched for a strategy to address the intrinsic thermal instability of conventional PHAs. According to CSU, its chemists “made fundamental changes to the structures of these plastics, substituting reactive hydrogen atoms responsible for thermal degradation with more robust methyl groups. This structural modification drastically enhances the PHAs’ thermal stability, resulting in plastics that can be melt-processed without decomposition.” CSU notes that the newly designed PHAs are also mechanically tough, “even outperforming the two most common commodity plastics: high-density polyethylene -- used in products like milk and shampoo bottles -- and isotactic propylene, which is used to make automotive parts and synthetic fibers.” CSU notes that the new PHA can be chemically recycled back to its building-block molecule with a simple catalyst and heat, and the recovered clean monomer can be reused to reproduce the same PHA again.
 
The work was supported by the U.S. Department of Energy’s (DOE) Bio-Optimized Technologies to keep Thermoplastics out of Landfills and the Environment (BOTTLE™), a DOE multi-organization consortium “focused on developing new chemical upcycling strategies for today’s plastics and redesigning tomorrow’s plastics to be recyclable-by-design.” More information is available in a Science article entitled “Chemically circular, mechanically tough, and melt-processable polyhydroxyalkanoates.”

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By Lynn L. Bergeson and Carla N. Hutton
 
As reported in our September 13, 2022, blog item, President Joseph Biden signed an Executive Order (EO) on September 12, 2022, creating a National Biotechnology and Biomanufacturing Initiative “that will ensure we can make in the United States all that we invent in the United States.” On March 22, 2023, the White House Office of Science and Technology Policy (OSTP) published a fact sheet announcing “new bold goals and priorities that will catalyze action inside and outside of government to advance American biotechnology and biomanufacturing”:

• Harnessing Biotechnology and Biomanufacturing Research and Development (R&D) to Further Societal Goals: On March 22, 2023, OSTP released a new report, Bold Goals for U.S. Biotechnology and Biomanufacturing: Harnessing Research and Development to Further Societal Goals, outlining a vision for what is possible with the power of biotechnology and biomanufacturing and the R&D needs to achieve this ambitious vision. Biden’s EO called on federal departments and agencies to assess the potential for biotechnology and biomanufacturing R&D to further five societal goals: climate change solutions; food and agricultural innovation; supply chain resilience; human health; and crosscutting advances. The report includes individual sections authored by the Department of Energy (DOE), the U.S. Department of Agriculture (USDA), the Department of Commerce (DOC), the Department of Health and Human Services (DHHS), and the National Science Foundation (NSF), in consultation with other agencies and departments, that are responsive to the President’s EO. The goals and R&D needs outlined in the report serve as a guide for public- and private-sector efforts to harness the full potential and power of biotechnology and biomanufacturing to develop innovative solutions in different sectors, create jobs at home, build stronger supply chains, lower costs for families, and achieve our climate goals. According to the fact sheet, OSTP will now lead the development of an implementation plan to address the R&D needs outlined in the report.
   
• Establishing Biomanufacturing Priorities for DOD: As part of the National Biotechnology and Biomanufacturing Initiative, DOD announced in September 2022 an investment of $1.2 billion in bioindustrial domestic manufacturing infrastructure to catalyze the establishment of a domestic bioindustrial manufacturing base accessible to U.S. innovators. On March 22, 2023, DOD released its Biomanufacturing Strategy to guide these investments, and its broader efforts in this critical technology field. This strategy, which will guide research efforts and collaboration with the private sector and allies, sets three key priorities: establishing the customers within DOD that stand to benefit from early-stage innovations, advancing biomanufacturing capabilities through innovation, and mapping the biomanufacturing ecosystem and tracking metrics that support future efforts. In support of the strategy, DOD issued a formal request for information on biomanufactured products and process capabilities that could help address defense needs and whose development and commercialization could be addressed by DOD investment.
   
• Assessing the Economic Value of the Nation’s Bioeconomy: DOC’s Bureau of Economic Analysis released a new report that assesses the feasibility of measuring the economic contributions of the U.S. bioeconomy. The report also includes an assessment of what is needed to measure these contributions better and more accurately.

According to the fact sheet, other deliverables from the EO are in development, including: a plan to expand training and education opportunities for the biotechnology and biomanufacturing workforce, a report on data needs for the bioeconomy, a national strategy for expanding domestic biomanufacturing capacity, actions to improve biotechnology regulation clarity and efficiency, and a plan for strengthening and innovating biosafety and biosecurity for the bioeconomy.

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By Lynn L. Bergeson and Carla N. Hutton
 
On March 27, 2023, the U.S. Environmental Protection Agency (EPA) announced that its Safer Choice program is accepting submissions for its 2023 Safer Choice Partner of the Year Awards. 88 Fed. Reg. 18135. The Safer Choice program certifies products containing ingredients that have met the program’s specific and rigorous human health and environmental toxicological criteria. According to EPA, the Safer Choice program allows companies to use its label on certified products that contain safer ingredients and perform, as determined by expert evaluation. EPA states that it developed the Partner of the Year Awards to recognize the leadership contributions of Safer Choice partners and stakeholders who have shown achievement in the design, manufacture, selection, and use of products with safer chemicals that further outstanding or innovative source reduction.
 
Similar achievement in the design, manufacture, selection, and use of Design for the Environment (DfE)-certified products will also make an organization eligible for the Partner of the Year Awards. The DfE program is a companion program to Safer Choice and certifies antimicrobial products. EPA states that the DfE logo may be used on certified products and helps consumers and commercial buyers identify products that meet the health and safety standards of the pesticide registration process required by the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), as well as the Safer Choice program’s stringent criteria for efficacy and effects on human health and the environment.
 
All Safer Choice stakeholders and program participants in good standing are eligible for recognition. Interested parties who would like to be considered for the award should submit to EPA an application detailing their accomplishments and contributions during calendar year 2022. EPA “especially encourages submission of award applications that show how the applicant’s work in the design, manufacture, selection, and use of those products promotes environmental justice, bolsters resilience to the impacts of climate change, results in cleaner air or water, improves drinking water quality, or advances innovation in packaging.” Submissions are due May 31, 2023. EPA will recognize award winners at a Safer Choice Partner of the Year Awards ceremony in fall 2023. More information on the 2023 Safer Choice Partner of the Year Awards, including the application form, submission process, and past winners, is available on EPA’s website.

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By Lynn L. Bergeson and Carla N. Hutton
 
The U.S. Department of Energy’s (DOE) Bioenergy Technologies Office (BETO) will host its 2023 Project Peer Review April 3-7, 2023. Projects in BETO’s research and development (R&D) portfolio will be presented to the public and systematically reviewed by external subject-matter experts from industry, academia, and federal agencies. Simultaneous review sessions of projects across the BETO technology areas will occur. The event will take place in person at the Grand Hyatt Denver in Denver, Colorado. The agenda is available online.

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By Lynn L. Bergeson and Carla N. Hutton
 
The U.S. Department of Energy’s (DOE) Bioenergy Technologies Office (BETO) will host a listening session at the 2023 Advanced Bioeconomy Leadership Conference (ABLC) to obtain stakeholder feedback on the next Billion-Ton Report. BETO seeks suggestions for making this product even more useful, as well as feedback on the 2016 Billion-Ton Report and related products. The anticipated 2023 Billion-Ton Report will build on previous national assessments that have calculated the potential supply of biomass in the United States. Speakers for the session will include:

• Matt Langholtz, Oak Ridge National Laboratory Bioenergy Resource and Engineering Systems Team Lead;
• Nichole Fitzgerald, BETO Program Manager;
• Mark Elless, BETO Technology Manager; and
• Melissa Ladd, BETO Senior Facilitator.

The session will be held on Thursday, March 23, 2023, at 3:45 p.m. (EDT), at the Mayflower Hotel located in Washington, D.C. Registration for ABLC 2023 is open.

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By Lynn L. Bergeson and Carla N. Hutton
 
On February 16, 2023, Representative Randy Feenstra (R-IA) introduced a legislative package that includes bills regarding researching the potential of biofuels to power jet engines and developing a commercially viable fuel cell system for cars and trucks powered exclusively by biofuels. The package includes:

• The Comparison of Sustainable Transportation (COST) Act would direct the Comptroller General of the U.S. Government Accountability Office (GAO) and the U.S. Secretary of Energy to compare the financial and environmental costs between replacing the entire federal gasoline-powered fleet with either electric vehicles or E-85 capable flex-fuel cars and trucks;
   
• The Biojet Fuel Research Act would direct the Federal Aviation Administration (FAA) to establish a working group focused on identifying research and development needs to produce biojet fuel. The working group would consist of the Bioenergy Technologies Office of the U.S. Department of Energy (DOE), the U.S. Department of Agriculture (USDA), biorefinery stakeholders, agriculture research universities, and others; and
   
• The Biofuel Cell Research Act would direct the DOE Secretary to establish a research, development, and demonstration program for a commercially viable fuel cell system that uses biofuels as the main fuel source.

Feenstra introduced similar legislation in the 117th Congress.
 

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By Lynn L. Bergeson and Carla N. Hutton
 
The U.S. Department of Energy’s (DOE) Bioenergy Technologies Office (BETO) recently announced the selection of five external collaborations totaling over $3.7 million to conduct research and development (R&D) needed to accelerate the U.S. biomanufacturing sector. Working with scientists at the Agile BioFoundry (ABF) consortium, these industry and academic groups will leverage national laboratory capabilities to address challenges in biomanufacturing. The projects include:

• University of California, Berkeley will address the pressing need for a scalable method for double-stranded ribonucleic acid (RNA) production for agricultural pesticide applications, employing microbial strain engineering and fermentation scale-up;
• Birch Biosciences will develop improved technologies that enable engineering of high-performance enzymes for economical and sustainable plastic recycling;
• Kiverdi will develop a platform for sequestering carbon dioxide to produce secreted recombinant proteins;
• University of Nebraska-Lincoln will expand the synthetic biology biosensor toolkit for Methanosarcina, a promising archaeal host organism that can be used to create fuels and renewable chemicals; and
• Azolla will leverage ABF’s capabilities to engineer a bacterium capable of using sunlight and carbon dioxide to produce nanocellulosic fiber to replace current unsustainable production practices in the textile industry.

The selected projects all directly contribute to producing renewable biofuels and biobased chemicals and materials. They also help ABF build foundational technologies critical for the decarbonization of the industrial and transportation sectors. Funded by BETO, ABF aims to advance biomanufacturing by uniting and expanding the capabilities of the national laboratories.

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By Lynn L. Bergeson and Carla N. Hutton
 
As reported in our January 4, 2023, blog item, on January 3, 2023, the U.S. Environmental Protection Agency (EPA) announced the release of a draft document entitled “Biofuels and the Environment: Third Triennial Report to Congress (External Review Draft)” for public comment. 88 Fed. Reg. 72. EPA’s Office of Research and Development (ORD) and Office of Air and Radiation (OAR), in consultation with the U.S. Departments of Agriculture (USDA) and Energy (DOE), prepared the document. The purpose of the report is to examine the effects of the Renewable Fuel Standard (RFS) Program on the environment, including the impacts to date and likely future impacts to the nation’s air, land, and water resources. The draft report focuses on the dominant biofuel sources in the United States: (1) domestic corn ethanol from corn starch; (2) domestic biodiesel from soybean oil; (3) domestic biodiesel from fats, oils, and greases (FOG); and (4) imported ethanol from Brazilian sugarcane.
 
ERG, an EPA contractor, is organizing an independent external peer review of the draft report. The peer review meetings are open to anyone who would like to attend as an observer and will include a brief public comment period on the first day (February 24, 2023). Registration is required. Panel peer review meetings will be held:

• February 24, 2023, 11:00 a.m.-6:45 p.m. (EST);
   
• February 27, 2023, 11:00 a.m.-6:30 p.m. (EST); and
   
• February 28, 2023, 1:00 p.m.-3:40 p.m. (EST).

Comments on the draft report are due March 6, 2023.

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By Lynn L. Bergeson and Carla N. Hutton
 
The U.S. Department of Energy (DOE) Bioenergy Technologies Office (BETO) will hold a webinar on February 22, 2023, entitled “DOE’s Progress Toward Meeting the Goals of the Sustainable Aviation Fuel Grand Challenge.” The Sustainable Aviation Fuels (SAF) Grand Challenge is a government-wide commitment to scale up production of SAF to 35 billion gallons per year by 2050 and reduce lifecycle aviation greenhouse gas (GHG) emissions by 50 percent compared to conventional fuel. According to BETO, the upcoming webinar is an effort to increase SAF awareness and communicate the progress and impact of the SAF Grand Challenge. Attendees will learn about DOE’s focus on:

• SAF priorities and program alignment with the SAF Grand Challenge Roadmap;
• Implementation planning; and
• Stakeholder engagement and outreach.

The webinar will feature speakers from BETO, including Director Dr. Valerie Reed, who will share information about the six action areas outlined in the Roadmap that support the Grand Challenge goals. Scheduled BETO speakers include:

• Dr. Valerie Reed: Director -- Program Overview;
• Zia Haq: Senior Analyst -- SAF Overview and Enabling End Use;
• Dr. Art Wiselogel: Oak Ridge Institute for Science and Education (ORISE) Fellow -- Feedstock Innovation;
• Dr. Ian Rowe: Technology Manager, Conversion Research and Development (R&D) -- Conversion Innovation;
• Dr. Mark Shmorhun: Technology Manager, Systems, Development, and Integration -- Building Regional SAF Supply Chains;
• Andrea Bailey: Technology Manager, Data, Modeling, and Analysis -- Policy and Valuation Analysis; and
• Sheila Dillard: Communications Lead -- Communicating Progress and Building Support.

Attendees can submit questions prior to the event, no later than February 17, 2023, by sending an email to .(JavaScript must be enabled to view this email address).

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By Lynn L. Bergeson and Carla N. Hutton
 
On February 8, 2023, the U.S. Department of Energy (DOE) announced $25.5 million in funding to enable the sustainable use of domestic biomass and waste resources, such as agricultural residues and algae, to produce low-carbon biofuels and bioproducts. DOE notes that this funding will advance the Biden Administration’s goals of delivering an equitable, clean energy future, and will put the United States on a path to achieve net-zero emissions, economy-wide, by 2050. According to DOE, the “Reducing Agricultural Carbon Intensity and Protecting Algal Crops” funding opportunity will improve the production of environmentally sustainable feedstocks for bioenergy through two topic areas:

• Climate-Smart Agricultural Practices for Low-Carbon Intensity Feedstocks; and
• Algae Crop Protection.

DOE states that “[r]ecognizing that decarbonizing transportation and agriculture are inherently linked when it comes to the thoughtful production and deployment of biofuels, this funding opportunity focuses on improving climate-smart agricultural practices that reduce the carbon intensity of biomass feedstocks used for biofuel production, and cultivating and protecting algae crops, an abundant and renewable biofuel source.” Both topic areas support DOE’s Sustainable Aviation Fuel (SAF) Grand Challenge goal of furthering the production of 35 billion gallons of SAF annually by 2050.
 
Concept papers are due by 5:00 p.m. (EDT) March 20, 2023, and full applications are due by 5:00 p.m. (EDT) on May 16, 2023.

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